Melatonin

Provings – Proving by Melanie Grimes
Melatonin is a hormone produced by the pineal gland. It plays a central role in regulating the circadian rhythm and sleep–wake cycle. Therapeutically, it has been used in conditions such as jet lag, SAD, depression, insomnia, and as supportive care in cancer.
Genius
A key remedy in insomnia, chronic stress, and disturbed or altered sleep–wake rhythms. It is frequently used as an intercurrent, especially where circadian rhythm disruption is central to the case.
Themes
Aggravation from night-shift work
Aggravation from irregular sleep schedules
Worse sleeping with lights on
Causative Factors
Prolonged sleep deprivation
Ailments from caring for or nursing loved ones
Chronic fatigue states
Clinical Indications
Amnesia and memory weakness
Chronic fatigue and drowsiness
Constipation
Depression
Headaches
Hyperactivity
Infertility
Insomnia, jet lag, and other sleep disorders
Night terrors, nightmares, and night watching
Seasonal Affective Disorder (SAD)
Neoplastic conditions, including breast cancer
Clinical Picture
The remedy is especially indicated in jet lag and circadian desynchronization due to drastic changes in sleep patterns. Symptoms may include night terrors, early awakening, insomnia, daytime drowsiness, and ailments arising from prolonged loss of sleep. Chronic fatigue is prominent.
DD: Opium, Coffea, Cocculus, Nux vomica.