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Aizoaceae has been mostly unknown in homeopathy. Only Mesembryanthemum cristallinum has been mentioned in older literature. In the fist version of the Plant theory Aizoaceae was placed in Aizoales together with families like Nyctaginaceae and Phytolaccaceae. This was based on the DNA studies in botany who grouped those families together. Only Phytolacca americana was known in homeopathy.
Practice in homeopathy with Aizoaceae did not produce very good results. This indicated that a revision was needed. This became also possible because some incidental results were present, more species were available in homeopathic potencies and provings had been done.
The first characteristic is that Aizoaceae are quite different from the other families in Aizoales. Aizoaceae are succulents, very soft, with thick leaves. The softness of the inside leaves shows a quality of Phase 2. And this is lacking in the other families. The second fact is that Aizoaceae has many genera, about 135 and 1800 species. The other families in Aizoales have about 50 genera. This resulted in the idea of treating Aizoaceae separately.
What was also curious that a case of Sceletium had aspects of Phase 7. This in contrast with the placement of Aizoacae in Phase 2 and Subphase 3.
This lead to the idea of raising Aizoaceae to the level of Order in Phase 2 and raising the subfamilies to the level of family and placing them in the several Subphases. This fitted also better with the results of several provings. Treating Aizoaceae as an oder does not affect the monophyly of it, it stays monophyletic.
The first split of Aizoaceae is Aizooideae. Aizooideae are relatively normal plants compared to the other Aoziaceae. This fits with Phase 1. The split of subfamily of Sesuvioideae is combined with Aizooideae.
The next split off is Mesembryanthemoideae, which is a clearly defined subfamily. This is so much so that there has been a tendency to fuse all genera of Mesembryanthemoideae into the genus Mesembryanthemum. This strategy is not copied in the plant theory, as the members of Mesembryanthemoideae have shown aspect of different Stages. Mesembryanthemoideae has been confirmed as Subphase 7.
Then the problem becomes more difficult. In phylogenetic studies all other Aizoaceae are placed in the subfamily Ruschioideae. It is the majority by far. And the subdivision is less clear. The tribe Dorotheantheae is close to Apatesieae and both have been confirmed as having qualities of Subphase 2. There they are placed as Dorotheanthoideae.
Delospermoideae is a next split off and has been confirmed as Subphase 6, with quite a few very good cases.
Bergeranthoideae has been confirmed as Subphase 3, as has been confirmed by a case of Carruanthes ringens.
The hardest problem is to split the rest of Ruschioideae into two subfamilies. It has been done in Lithopsoideae in Subphase 4 and a restricted Ruschioideae in Subphase 5. But the delimitation of the two is quite unsure yet as the DNA analysis do not give clear results. The botanical studies are inconclusive till now.

The allocation of families and subfamilies of Aizoales has been difficult in the past, giving poor results. The update has been much more accurate and predictive, giving good cases regularly. Some parts need still further study though. And the allocation of genera to Stages needs further research.

A consequence of classification is that the former families of Aizoales cannot be maintained in Phase 2. They have been transferred to Phase 3. Further study has shown that that fits better with old cases and new prescriptions.
The fortunate aspect is that this transfer gives more fulness to Phase 3, Physenales. In the first version of the Plant theory Phase 3 contained Physenales, but the families in it are very small, lacking the capability to cover all aspect of the Subphase and Stages of Phase 3. Incorporating Nyctaginaceae, Phytolaccaeae and Molluginacaeae has made the plant theory more accurate.

Aizoales Subphases
1. Sesuvioideae
2. Drosanthemoideae
3. Bergeranthoideae
4. Lithopsoideae
5. Russchioideae
6. Delospermoideae
7. Mesembryanthemoideae

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